Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 16, Pages 5684-5687Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b01705
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Funding
- National Science Foundation [DGE-1111169]
- Amgen
- Shionogi Co., Ltd.
- NIH [NIGMS R35GM118191-01, GM111805-01]
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An asymmetric Ni-catalyzed reductive cross-coupling of (hetero)aryl iodides and benzylic chlorides has been developed to prepare enantioenriched 1,1-diarylalkanes. As part of these studies, a new chiral bioxazoline ligand, 4-heptyl-BiOX (L1), was developed in order to obtain products in synthetically useful yield and enantioselectivity. The reaction tolerates a variety of heterocyclic coupling partners, including pyridines, pyrimidines, indoles, and piperidines.
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