Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 20, Pages 6811-6814Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b02455
Keywords
-
Categories
Funding
- National Basic Research Program of China [973-2015CB856600]
- National Nature Science Foundation of China [21532009, 21421091, 21472219]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB-20000000]
- CAS Interdisciplinary Innovation Team
- Program of Shanghai Academic/Technology Research Leader
Ask authors/readers for more resources
We have developed a copper-catalyzed enantioselective intermolecular aminoarylation of alkenes using a novel N-fluoro-N-alkylsulfonamide as the amine reagent, which could react with the Cu(I) catalyst to release a related amino radical. After addition to styrene, the generated benzylic radical could couple with a chiral L*(CuAr)-Ar-II complex to achieve enantioselective arylation. Various optical 2,2-diarylethylamines were efficiently synthesized from simple styrenes with high enantioselectivity, and these products can serve as valuable synthons toward bioactive molecules' synthesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available