Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 5, Pages 1762-1765Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b12142
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Funding
- Nanjing Tech University [39837110]
- SICAM Fellowship, Jiangsu National Synergetic Innovation Center for Advanced Materials
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Using alpha,alpha-difluoromethylene alkyne as a nontraditional one-carbon reaction partner, a synthetically novel method for the construction of isoindolin-l-one derivatives via Rh(III)-catalyzed [4+1] annulation reaction is reported. The 2-fold C-F bond cleavage not only enables the generation of desired product under an overall oxidant-free condition but also results in a net migration of carbon carbon triple bond. In addition, the present reaction protocol exhibits a tolerance of a wide spectrum of functional groups due to the mild reaction conditions employed.
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