Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 28, Pages 9698-9707Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b05202
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Funding
- UK Engineering and Physical Sciences Research Council (EPSRC) [EP/M01083X/1]
- EPSRC [EP/M01083X/1, EP/K039520/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K039520/1, EP/M01083X/1] Funding Source: researchfish
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A series of aromatic-paneled (Fe4L6)-L-II cages was synthesized through iron(II)-templated subcomponent self-assembly of 2-formylpyridine and C-2-symmetric diamine building blocks having differing geometries, including many with a large degree of lateral offset between metal-binding sites. The new cages were characterized using X-ray crystallography, NMR spectroscopy, and mass spectrometry. Investigations of the guest binding properties of the cages provided insights into the structural factors important for the observation of guest binding. Both the size and arrangement of the aromatic panels were shown to be crucial for achieving effective encapsulation of large hydrophobic guests, including fullerenes, polycyclic aromatic hydrocarbons, and steroids, with subtle differences in the structure of subcomponents resulting in incommensurate effects on the binding abilities of the resulting hosts. Cages with large, offset aromatic panels were observed to be the most effective hosts as a result of a preference for a ligand conformation where the aromatic panels lie tangent to the edges of the tetrahedron, thus maximizing cavity enclosure.
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