Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 10, Pages 3595-3598Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b11533
Keywords
-
Categories
Funding
- NSERC Discovery Grant
- MSFHR Career Investigator Award
- Hoffmann-La Roche Fellowship (RPF)
- CCSRI Innovation Grant
- National Research Council of Canada
Ask authors/readers for more resources
A mild and selective photocatalytic C-H BF-fluorination reaction has been developed that provides direct access to BF-fluorinated amino acids. The biodistribution and uptake of three F-labeled leucine analogues via LAT1 mediated transport in several cancer cell lines is reported. Positron emission tomography imaging of mice bearing PC3 (prostate) or U87 (glioma) xenografts using S-[F-18]-fluorohomoleucine showed high tumor uptake and excellent tumor -visualization, highlighting the utility of this strategy for rapid tracer discovery for oncology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available