Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 25, Pages 8547-8551Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b02801
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Funding
- NIH [GM077173, EB022641]
- NSF [DMR1452122]
- [CHE-1506725]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1452122] Funding Source: National Science Foundation
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Active intracellular transport is a central mechanism in cell biology, directed by a limited set of naturally occurring signaling peptides. Here, we report the first nonpeptide moiety that recruits intracellular transport machinery for nuclear targeting. Proteins synthetically modified with a simple aromatic boronate motif are actively trafficked to the nucleus via the importin alpha/beta pathway. Significantly, proteins too large to passively diffuse through nuclear pores were readily imported into the nucleus through this boronate-mediated pathway. The use of this simple motif to provide active intracellular targeting provides a promising strategy for directing subcellular localization for therapeutic and fundamental applications.
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