Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 26, Pages 8808-8811Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b04985
Keywords
-
Categories
Funding
- Spanish Government [MAT2015-64139-C4-1-R]
- Generalitat Valenciana [PROMETEOII/2014/047]
- Spanish Ministry of Economy
- Generalitat Valenciana
- Spanish Government
- La Caixa foundation
- CNIO
- European Regional Development Fund (SAF project)
- European Research Council (ERC)
- Botin Foundation
- Banco Santander (Santander Universities Global Division)
- Ramon y Cajal Programme Senior Grant
- RETOS National Programme for Research (MINECO)
- Cancer Research UK
- CRUK Cambridge Centre Early Detection Programme
Ask authors/readers for more resources
A naphthalimide-based two-photon probe (AHGa) for the detection of cell senescence is designed. The probe contains a naphthalimide core, an L-histidine methyl ester linker, and an acetylated galactose bonded to one of the aromatic nitrogen atoms of the L-histidine through a hydrolyzable N-glycosidic bond. Probe AHGa is transformed into AH in senescent cells resulting in an enhanced fluorescent emission intensity. In vivo detection of senescence is validated in mice bearing tumor xenografts treated with senescence-inducing chemotherapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
