Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 5, Pages 1766-1769Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b12180
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Funding
- Wellcome Trust Senior Investigator award [099232/z/12/z]
- Cancer Research U.K. [C14303/A17197]
- Wellcome Trust [099232/Z/12/Z] Funding Source: researchfish
- Wellcome Trust [099232/Z/12/Z] Funding Source: Wellcome Trust
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5-Hydroxymethylcytidine (hm(5)C) was recently identified as a direct metabolite of m(5)C in RNA. We investigated the stability of hm(5)C in human cells using bio-isotopologues and LC-MS/HRMS. This has led to the discovery of a second oxidative metabolite of m(5)C in RNA, namely 2'-O-methyl-S-hydroxymethylcytidine (hm(5)Cm). Subsequent quantitative analysis of total RNA from higher organisms revealed varying levels and TET-independent formation of this new RNA modification.
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