Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 20, Pages 6819-6822Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b02829
Keywords
-
Categories
Funding
- University of California, San Diego
Ask authors/readers for more resources
Herein we describe concise enantioselective chemical syntheses of (-)-viridin and (-)-viridiol.,Our convergent approach couples two achiral fragments of similar complexity and employs an enantioselective intramolecular Heck reaction to set the absolute stereo chemical configuration of an all-carbon quaternary stereo center. To complete the syntheses of these base- and nucleophile-sensitive natural products, we conduct carefully orchestrated site- and diastereoselective oxidations and other transformations. Our work is the first to generate these targets as single enantiomers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available