Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 24, Pages 8114-8117Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b04374
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Funding
- Robert A. Welch Foundation [F-0038]
- NIH-NIGMS [RO1-GM069445]
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Using an iridium catalyst modified by PhanePhos, CF3-allenes react with methanol to form branched products of hydrohydroxymethylation as single regioisomers with excellent levels of enantiomeric enrichment. This hydrogen autotransfer process enables catalytic enantioselective formation of acyclic CF3-bearing all carbon quaternary stereocenters in the absence of stoichiometric metals or byproducts.
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