Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 38, Pages 13579-13584Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b08158
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Funding
- National University of Singapore [R-143-000-645-112, R-143-000-665-114]
- GSK-EDB [R-143-000-687-592]
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A direct hydroalkylation of disubstituted alkynes with unfunctionalized ethers and amides was achieved in an atom-efficient and additive-free manner through the synergistic combination of photoredox and nickel catalysis. The protocol was effective with a wide range of internal alkynes, providing products in a highly selective fashion. Notably, the observed regioselectivity is complementary to conventional radical addition processes. Mechanistic investigations suggest that the photoexcited iridium catalyst facilitated the nickel activation via single-electron transfer.
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