Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 13, Pages 4615-4618Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b11895
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Funding
- U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research [DE-AC02-05CH11231]
- Novo Nordisk Fonden [NNF10CC1016517] Funding Source: researchfish
- Directorate For Engineering [1437775] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys [1437775] Funding Source: National Science Foundation
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Dicarboxylic acids are commodity chemicals used in the production of plastics, polyesters, nylons, fragrances, and medications. Bio-based routes to dicarboxylic acids are gaining attention due to environmental concerns about petroleum-based production of these compounds. Some industrial applications require dicarboxylic acids with specific carbon chain lengths, including odd carbon species. Biosynthetic pathways involving cytochrome P450-catalyzed oxidation of fatty acids in yeast and bacteria have been reported, but these systems produce almost exclusively even-carbon species. Here we report a novel pathway to odd-carbon dicarboxylic acids directly from glucose in Escherichia coli by employing an engineered pathway combining enzymes from biotin and fatty acid synthesis. Optimization of the pathway will lead to industrial strains for the production of valuable odd carbon diacids.
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