4.8 Article

Nickel-Catalyzed Stereoselective Arylboration of Unactivated Alkenes

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 140, Issue 1, Pages 159-162

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b12160

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Funding

  1. NIH [5R01GM114443]
  2. Vice Provost for Research through the Research Equipment Fund
  3. Indiana University
  4. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM114443] Funding Source: NIH RePORTER

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A Ni-catalyzed method for arylboration is disclosed. The method allows for highly stereoselective arylboration of unactivated alkenes. The reactions utilize a simple Ni-catalyst and work with a broad range of alkenes and aryl bromides. The products represent useful intermediates for chemical synthesis due to the versatility of the C-B bond. Preliminary mechanistic details of the method are also disclosed.

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