Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 33, Pages 11353-11356Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b07078
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Funding
- NIHGMS [R01 GM103558-05]
- Shanghai Institute of Organic Chemistry
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A mechanism that enables direct aldehyde C-H functionalization has been achieved via the synergistic merger of photoredox, nickel, and hydrogen atom transfer catalysis. This mild, operationally simple protocol transforms a wide variety of commercially available aldehydes, along with aryl or alkyl bromides, into the corresponding ketones in excellent yield. This C-H abstraction coupling technology has been successfully applied to the expedient synthesis of the medicinal agent haloperidol.
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