Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 6, Pages 2148-2151Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b11401
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Funding
- NSF BEST-IGERT
- University of California, Irvine
- NIH [1DP2GM119164, 1RO1MH109588]
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Stringent chemical methods to profile RNA expression within discrete cellular populations remains a key challenge in biology. To address this issue, we developed a chemical genetic strategy for metabolic labeling of RNA. Cell-specific labeling of RNA can be profiled and imaged using bioorthogonal chemistry. We anticipate that this platform will provide the community with a much-needed chemical toolset for cell-type specific profiling of cell-specific transcriptomes derived from complex biological systems.
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