Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 41, Pages 14388-14391Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b09219
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Funding
- NSF [CHE 161107]
- NASA Habitable Worlds grant [NNX15AP20G]
- NIH/CU Molecular Biophysics Training Program
- NASA [799879, NNX15AP20G] Funding Source: Federal RePORTER
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1611107] Funding Source: National Science Foundation
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Biological membranes are a crucial aspect of living systems, controlling the organization and distribution of different chemical components. Control of membrane permeability is especially important for processes such as electron transport in metabolism and signal propagation in nerve cells. In this work, we show that the amino acid phenylalanine produces increased membrane permeability, which is likely responsible for some of the deleterious symptoms associated with high biological phenylalanine concentrations that occur with the genetic disorder phenylketonuria.
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