Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 18, Pages 6321-6328Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b12622
Keywords
-
Categories
Funding
- Australian Research Council
- Queensland Government
- Australian National Fabrication Facility
- Australian Microscopy and Microanalysis Research Facility at the Centre for Microscopy and Microanalysis, The University of Queensland
Ask authors/readers for more resources
Asymmetric mesoporous silica nanoparticles (MSNs) with controllable head tail structures have been successfully synthesized. The head particle type is tunable (solid or porous), and the tail has dendritic large pores. The tail length and tail coverage on head particles are adjustable. Compared to spherical silica nanoparticles with a solid structure (Stober spheres) or large-pore symmetrical MSNs with fully covered tails, asymmetrical head tail MSNs (HTMSNs) show superior hemocompatibility due to reduced membrane deformation of red blood cells and decreased level of reactive oxygen species. Moreover, compared to Stober spheres, asymmetrical HTMSNs exhibit a higher level of uptake and in vitro maturation of immune cells including dendritic cells and macrophage. This study has provided a new family of nanocarriers with potential applications in vaccine development and immunotherapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available