Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 62, Pages 9124-9127Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc03124c
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Funding
- Ministry of Science and Technology of Taiwan [MOST 107-2113-M-007-023]
- National Tsing Hua University [108QI008E1]
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DC-SIGN and langerin receptors both bind to oligomannose but lead to opposite effects upon encountering HIV. Because selective targeting of DC-SIGN can lead to anti-viral effects, we developed a glycoconjugate, which provides over 4800-fold selectivity for DC-SIGN over langerin, by controlling the oligomannose pattern on a polyproline tetra-helix macrocycle scaffold.
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