Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 39, Pages 13882-13896Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b07706
Keywords
-
Categories
Funding
- National Institute of General Medical Sciences. [R01 GM084906]
- NSERC
- NSF GRFP [DGE 1106400]
- NIH [5F31GM095238, SI0-RR027172, SRR023679A, 1S10RR016634-01, GM68933, S10OD023532]
- NSF [CHE-9633007, CHE-0130862]
Ask authors/readers for more resources
The secondary metabolites that comprise the diterpenoid alkaloids are categorized into C-18, C-19, and C-20 families depending on the number of contiguous carbon atoms that constitute their central framework. Herein, we detail our efforts to prepare these molecules by chemical synthesis, including a photochemical approach, and ultimately a bioinspired strategy that has resulted in the development of a unifying synthesis of one C-18 (weisaconitine D), one C-19 (liljestrandinine), and three C-20 (cochlearenine, paniculamine, and N-ethyl-1a-hydroxy-17-veratroyldictyzine) natural products from a common intermediate.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available