4.8 Article

Reactivity of Lithium β-Ketocarboxylates: The Role of Lithium Salts

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 48, Pages 17414-17420

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b08450

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Funding

  1. Spanish Ministerio de Economia, Industria y Competitividad [CTQ2016-80503-P]
  2. Fondos FEDER
  3. NSF [1464538]
  4. Spanish Ministerio de Economia y Competitividad [BES-2011-043933]
  5. Direct For Mathematical & Physical Scien
  6. Division Of Chemistry [1464538] Funding Source: National Science Foundation

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Lithium beta-ketocarboxylates 1(COOLi), prepared by the reaction of lithium enolates 2(Li+) with carbon dioxide, readily undergo decarboxylative disproportionation in THF solution unless in the presence of lithium salts, in which case they are indefinitely stable at room temperature in inert atmosphere. The availability of stable THF solutions of lithium beta-ketocarboxylates 1(COOLi) in the absence of carbon dioxide allowed reactions to take place with nitrogen bases and alkyl halides 3 to give alpha-alkyl ketones 1(R) after acidic hydrolysis. The sequence thus represents the use of carbon dioxide as a removable directing group for the selective monoalkylation of lithium enolates 2(Li+). The roles of lithium salts in preventing the disproportionation of lithium beta-ketocarboxylates 1(COOLi) and in determining the course of the reaction with bases and alkyl halides 3 are discussed.

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