Journal
CANCER JOURNAL
Volume 25, Issue 4, Pages 272-281Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PPO.0000000000000389
Keywords
ALCHEMIST; ALK; LungMAP; MPACT; NCI-MATCH; Pediatric MATCH; precision medicine
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Funding
- Intramural NIH HHS [Z99 CA999999] Funding Source: Medline
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With advances in genetic testing and its common usage, the field of precision medicine has exploded in the field of oncology. The National Cancer Institute is uniquely positioned to lead in this area of research through its wide network of investigators, partnerships with pharmaceutical companies in drug development, and laboratory capabilities. It has developed a portfolio of trials as part of a Precision Medicine Initiative that uses various basket/umbrella designs to increase the understanding of treatment of cancer through genetic selection and targeted therapies. This article describes these trials, ALCHEMIST, LungMAP, NCI/NRG ALK Trial, MPACT, NCI-MATCH, and pediatric MATCH, and their contributions to the area of precision medicine.
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