Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 63, Pages 9363-9366Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc03846a
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Funding
- National High Technology Research and Development Program 863 of China [SS2015AA020405]
- National Natural Science Foundation of China [81830089, 81537009, 81502026, 51573161]
- Zhejiang Natural Science Foundation [LQ16H180002, LY18H160026]
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We developed a biodegradable, oncosensitive, megamer-based delivery system for miRNA therapy. The miRNA nanotherapeutics, activatable by stepwise stimulation of acidity and reduction mimicking tumor microenvironment, efficiently improve liver-specific miR-122 expression, increasing the possibility of translational application of miR-122 therapy against liver cancer.
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