Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 63, Pages 9367-9370Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc04758a
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Funding
- National Natural Science Foundation of China [21871178, 21702135]
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An efficient method for the preparation of chiral sulfenylated lactones has been described based on Lewis base-catalyzed enantioselective sulfenylation of unsaturated carboxylic acids. The scope of this method includes two enantioselective cyclization reactions: 5-endo and 6-exo thiolactonizations of alkenes. Two types of lactones were obtained with up to 95% ee and 99% yield. Additionally, this methodology has been applied in the formal syntheses of bioactive natural products (-)-nicotlactone B and (-)-galbacin.
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