Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 63, Pages 9311-9314Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc04077c
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Funding
- National Natural Science Foundation of China [61871183, 21834001]
- Shanghai Rising-Star Program [19QA1402300]
- National Ten Thousand Talent Program for young top-notch talent
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Discrimination between cysteine and homocysteine at the single-molecule level is achieved within a K238Q mutant aerolysin nanopore, which provides a confined space for high spatial resolution to identify the amino acid difference with a 5 '-benzaldehyde poly(dA)(4) probe. Our strategy allows potential detection and characterization of various amino acids and their modifications, and provides a crucial step towards developing nanopore protein sequencing devices.
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