Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 76, Issue 4, Pages 655-661Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2016.11.043
Keywords
Dermatology Life Quality Index; patient-reported outcome; psoriasis; secukinumab
Categories
Funding
- University of Connecticut from AbbVie
- Janssen
- AbGenomics
- AbbVie
- Amgen
- Anacor
- Canfite Biopharma
- Celgene
- Clinuvel
- Coronado Biosciences
- Ferndale
- Lilly
- Janssen Biotech
- LEO Pharma
- Merz
- Novartis
- Pfizer
- Sandoz
- Sun Pharmaceuticals
- Valeant
- Aqua
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Background: Psoriasis is a chronic condition with negative impact on patients' quality of life that most often requires lifelong effective and safe treatment. Objective: This analysis focused on the effect of secukinumab treatment on patient-reported health-related quality of life as assessed by the Dermatology Life Quality Index (DLQI) in patients with moderate to severe psoriasis. Methods: The proportion of subjects achieving DLQI score 0/1 response at week 24, time to DLQI score 0/1 response, and sustained DLQI score 0/1 response up to week 52 were compared between secukinumab and etanercept. Results: Of 1470 subjects, 1144 received secukinumab and 326 received etanercept. DLQI score 0/1 response rates were significantly higher for secukinumab than for etanercept at week 24. The median time to DLQI score 0/1 response was significantly shorter for secukinumab versus etanercept (12 vs 24 weeks; P < .01). The majority of secukinumab-treated subjects achieved DLQI score 0/1 response at week 24 and sustained it through week 52 along with a 90% to 100% reduction in the Psoriasis Area and Severity Index total score response. Limitations: Placebo comparisons are limited during the maintenance period because of rerandomization at week 12. Conclusion: Secukinumab treatment provided faster and greater sustained improvements in quality of life than etanercept over 52 weeks, consistent with greater clinical response.
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