Journal
ACS APPLIED BIO MATERIALS
Volume 2, Issue 8, Pages 3630-3638Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.9b00483
Keywords
mesoporous silica nanoparticles; gold nanoparticles; CpG-ODNs; cancer immunotherapy; photothermal therapy
Funding
- National Research Foundation (NRF) under the Ministry of Science and ICT, Republic of Korea [2019R1A2C2004765, 2010-0027955]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI17C0076]
Ask authors/readers for more resources
Cancer immunotherapy is a treatment that utilizes the host immune system to fight against cancer. Inducing a cancer antigen-specific adaptive immune response is key in cancer immunotherapy. Although diverse immune cells including dendritic cells (DCs) and T cells infiltrate a tumor, the activation of such immune cells is inhibited, owing to an immunosuppressive tumor microenvironment. In this study, we propose mesoporous silica nanoparticles (XL-MSNs) decorated with gold nanoparticles (Au@XL-MSNs) for the delivery of a high amount of CpG-ODNs to the tumor site to activate DCs infiltrated within the tumor for the induction of an antigen-specific adaptive immune response. During an in vitro test, CpG-ODNs delivered using Au@XL-MSNs were shown to be more effectively internalized by bone-marrow-derived dendritic cells (BMDCs), resulting in an enhanced expression of costimulatory molecules and an increased secretion of pro-inflammatory cytokines compared to soluble CpG-ODNs. Furthermore, an in vivo test demonstrated a more significant tumor growth inhibition and an enhanced survival rate result from the intratumoral injection of Au@XL-MSN-CpG compared to that treated using soluble CpG-ODNs. Furthermore, through the induction of a photothermal effect based on the assembled AuNPs on XL-MSNs, an enhancement of the cancer immunotherapy was achieved by generating a cancer antigen at the tumor site, which can be processed by tumor-infiltrated DCs. These findings suggest that our approach can be applied as a synergistic platform for efficient cancer immunotherapy, enabling a delivery of immunostimulating signals as well as in situ antigen generation through a photothermal effect.Y
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available