Impact of resveratrol supplementation on inflammatory, antioxidant, and periodontal markers in type 2 diabetic patients with chronic periodontitis

Background: Diabetes mellitus and periodontal disease are two common and chronic diseases with bidirectional relationship influence public health and quality of life. The aims of this study was to study the impact of resveratrol supplementation in adjunct with non-surgical periodontal therapy on inflammatory, antioxidant, and periodontal markers in patients with type 2 diabetes with periodontal disease. Materials and methods: In this randomized clinical trial, 43 patients with diabetes and chronic periodontitis were randomly allocated into two intervention and control groups receiving either resveratrol supplements or placebo for 4 weeks. Serum levels of interleukin 6 (IL6), tumor necrosis factor alpha (TNF alpha), total antioxidant capacity (TAC) and clinical attachment loss (CAL) as the main index of periodontal marker were measured pre-intervention and post-intervention. Results: In the intervention group, the mean serum level of IL6 was reduced significantly (P = 0.039) post-intervention (2.19 +/- 1.09 and 1.58 +/- 1.06). No significant differences were seen in the mean levels of IL6, TNF alpha, TAC and CAL between two groups post-intervention. Conclusions: It is suggested that daily consumption of resveratrol supplement may not change TNF alpha, TAC and CAL, but it would be beneficial in reducing serum levels of IL6. Therefore, further studies are suggested to investigate the effects of resveratrol supplementation along with NST on periodontal status. (C) 2019 Published by Elsevier Ltd on behalf of Diabetes India.