Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 7, Issue 31, Pages 4758-4762Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9tb00685k
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Funding
- Science and Technology Foundation of Sichuan Province [2018RZ0044]
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An all in one nano-system with active-targeting, enzyme-triggered deshielding and positive-charge characteristics was fabricated for chemo/photo-combination therapy to allow efficient tumor targeting, cellular internalization and lysosomal escape. The deshielding of NPs was induced by enzyme triggered degradation of the NP shell, and consequently exposure of the positively charged core accelerates escape of NPs from the lysosome to exert anticancer effects with high efficiency.
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