Journal
DALTON TRANSACTIONS
Volume 48, Issue 31, Pages 11978-11984Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9dt01806a
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Funding
- Science and Engineering Research Board (SERB), Department of Science and Technology (DST), India [EMR/2016/005150]
- MHRD
- UGC
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We report an efficient protocol for the catalytic chemo-selective reduction of tert-amides with pinacolborane (HBpin) to afford the corresponding amines in high yields using aluminium complexes [kappa(2)-{Ph2P(X)NC9H6N}Al(Me)(2)] [X = S (2a), Se (2b)] as pre-catalysts at room temperature. The aluminium complexes were prepared from the reaction of [Ph2P(X)NC9H6N] [X = S (1a), Se (1b)] and trimethylaluminium in toluene. The solid-state structure of complex 2b is established. Tertiary amides with a wide array of electron-withdrawing and electron-donating functional groups were easily converted to the desired products through the selective cleavage of the amides' CO bond by aluminium hydride as an active species. A kinetic study of the catalytic reaction is also reported.
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