Journal
CHEMICAL SOCIETY REVIEWS
Volume 48, Issue 16, Pages 4515-4618Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cs00872h
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Funding
- Spanish Ministerio de Economia, Industria y Competitividad
- Agencia Estatal de Investigacion (AEI)
- Fondo Europeo de Desarrollo Regional (FEDER, EU) [CTQ2016-76782-P, CTQ2016-81797-REDC, CTQ2017-85093-P]
- Generalitat Valenciana [PROMETEOII/2014/017]
- University of Alicante
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Metal-catalyzed regiodivergent reactions allow control over regioselectivity in the synthesis of a wide range of organic products. Starting from the same material, it is possible to prepare different regioisomers just by appropriately choosing the catalyst or by modifying the reaction conditions. Therefore, these regiodivergent methodologies should be included as the key factor in the concept of efficiency and atom economy in synthetic organic chemistry. The synthetic potential of this subject has been demonstrated mainly in addition reactions to unsaturated carbon-carbon bonds, allylic and propargylic nucleophilic substitutions, C-H activation reactions, cross-couplings, and intramolecular or intermolecular cyclizations. This review article overviews the development and rationalization of regiodivergence in these fundamental reactions in the last 15 years.
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