4.7 Article

Molecular recognition of organophosphorus compounds in water and inhibition of their toxicity to acetylcholinesterase

Journal

CHEMICAL COMMUNICATIONS
Volume 55, Issue 66, Pages 9797-9800

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc04603h

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Funding

  1. National Natural Science Foundation of China [21772083, 21822104]
  2. Shenzhen Science and Technology Innovation Committee [JCYJ20180504165810828, KQJSCX 20170728162528382]
  3. Shenzhen Nobel Prize Scientists Laboratory Project [C17783101]

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Molecular tubes with hydrogen bonding donors in their deep hydrophobic cavities are able to selectively bind organophosphorus compounds in water through hydrogen bonding and the hydrophobic effect. They can also be used as a fluorescent sensor for nerve agent simulants and as an inhibitor to reduce the toxicity of paraoxon to acetylcholinesterase.

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