Journal
JOURNAL OF FUNCTIONAL BIOMATERIALS
Volume 10, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/jfb10030034
Keywords
stimuli-responsiveness; drug release; drug delivery; thermo-responsive materials; enzyme-responsive materials; pH-responsive materials; shape-memory materials
Funding
- Tennessee Doctoral Research Fellowship
- National Science Foundation
- National Institute of Arthritis and Musculoskeletal and Skin Disease of the National Institutes of Health (NIH) [R01AR066050]
- National Institute of Dental and Craniofacial Research of the National Institutes of Health [R01DE026759]
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Over the past 10 years, stimuli-responsive polymeric biomaterials have emerged as effective systems for the delivery of therapeutics. Persistent with ongoing efforts to minimize adverse effects, stimuli-responsive biomaterials are designed to release in response to either chemical, physical, or biological triggers. The stimuli-responsiveness of smart biomaterials may improve spatiotemporal specificity of release. The material design may be used to tailor smart polymers to release a drug when particular stimuli are present. Smart biomaterials may use internal or external stimuli as triggering mechanisms. Internal stimuli-responsive smart biomaterials include those that respond to specific enzymes or changes in microenvironment pH; external stimuli can consist of electromagnetic, light, or acoustic energy; with some smart biomaterials responding to multiple stimuli. This review looks at current and evolving stimuli-responsive polymeric biomaterials in their proposed applications.
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