Journal
JOURNAL OF SUPERCRITICAL FLUIDS
Volume 130, Issue -, Pages 282-291Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.supflu.2017.06.010
Keywords
N-acetylcysteine; SEDS; Zebrafish; Supercritical CO2; Anxiolytics
Categories
Funding
- CAPES
- CNPq [478520/2013-1]
Ask authors/readers for more resources
The micronization techniques by supercritical fluid have been gaining more prominence especially in the pharmaceutical area. N-acetylcysteine (NAC) is a mucolytic which has emerged as a promising molecule for the treatment of neuropsychiatric disorders. This work aims to study the micronization process of NAC by the anti solvent SEDS technique, and to evaluate both in vitro and in vivo improvements in the properties of this compound. Herein we demonstrate that the micronization process led to a 245-fold reduction in particle size. In vitro tests showed an increase in dissolution rate, in antioxidant activity and beyond modification of the crystalline structure. In the in vivo tests, it was observed that the micronization process decreased the minimum effective concentration of NAC that induced anxiolytic-like effects in zebrafish. Micronization may thus increase bioavailability and potentiate the therapeutic effect of drugs, opening new horizons in the area of supercritical fluid micronization in the pharmaceutical industry.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available