Journal
JOURNAL OF DIETARY SUPPLEMENTS
Volume 16, Issue 5, Pages 550-563Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/19390211.2018.1472706
Keywords
genistein; oxidative stress; flavonoids; alpha synuclein; Drosophila; Parkinson's disease
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Funding
- Indian Council of Medical Research (ICMR), New Delhi [59/58/2011/BMS-TRM]
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Parkinson's disease (PD) is the second-most common neurodegenerative disorder and is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta. Oxidative stress has also been linked with the progression of PD, hence the involvement of a natural plant product could offer neuroprotection. The present study deals with the effect of genistein on the transgenic flies expressing normal human alpha synuclein panneurally. The PD flies were exposed to 10, 20, 30, and 40 mu M of genistein (mixed in diet) for 24 days. A significant dose-dependent increase in the life span and delay in the loss of climbing ability were observed in the PD flies exposed to genistein (p < .05). A significant dose-dependent decrease in oxidative stress markers and increase in dopamine content were observed in PD flies exposed to genistein. However, the exposure of genistein did not inhibit the expression of alpha-synuclein in the brains of PD flies.
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