Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 67, Pages 9967-9970Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc03870a
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Funding
- Natural Science Foundation of China [21775081]
- Key Research and Development Project of Shandong Province [2018GSF121010]
- Postdoctoral Science Foundation of China [2015M572074]
- Shandong Provincial Key Laboratory Open Fund [ZDSYS-KF201501]
- Key Laboratory Open Fund [SATM201602]
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Herein, a seesaw ratiometric (SR) probe is designed which integrates fluorescence and surface enhanced Raman scattering (SERS) technology. Fluorescence imaging enables tracking of the spatiotemporal dynamic behaviour of telomerase. Meanwhile, SERS reverse ratiometric measurement can enable sensitive detection of telomerase activity in single living cells.
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