Journal
JOURNAL OF SULFUR CHEMISTRY
Volume 39, Issue 2, Pages 151-163Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17415993.2017.1402332
Keywords
3,4-Dihydropyrimidin-2(1H)-one; lithium N,N-diisopropylamide; biginelli- type; phenylacetone; urea/thiourea; kinetic-thermodynamic
Categories
Ask authors/readers for more resources
An efficient one-pot regioselective synthesis of various novel 3,4-dihydropyrimidin-2(1H)-one (DHPMs) via a three-component Biginelli-type condensation of aldehyde, phenylacetone and urea/thiourea under two different based-catalyzed conditions is described. In kinetic control path, lithium N, N-diisopropylamide (LDA-20 mol % generated in situ from n-BuLi and diisopropylamine) was used as the base, in tetrahydroforane (THF) as the solvent at 0 degrees C. Thermodynamic control path was run with NaH as the base, in EtOH as the solvent under reflux status. The simple procedure, mild base-catalytic reaction conditions, no column chromatography and good to high yields are important features of this protocol. [GRAPHICS] .
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available