Journal
CELL CHEMICAL BIOLOGY
Volume 26, Issue 8, Pages 1095-+Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2019.04.010
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Funding
- University of Granada [CS2016-6]
- Garantia Juvenil'' contract from the European Social Fund
- Andalusian Regional Government
- Formacion Profesorado Universitario'' (FPU) PhD fellowship from the Government of Spain (MINECO) [FPU15/03294]
- Howard Hughes Medical Institute [IECS-55007420]
- Trading y Bolsa para Torpes, Granada, Spain
- European Research Council (ERC) [ERC-STG-2012-309433]
- MINECO-FEDER [SAF2017-89745-R]
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Retrotransposons are a type of transposable element (TE) that have amplified to astonishing numbers in mammalian genomes, comprising more than a third of the human and mouse genomes. Long interspersed element class 1 (LINE-1 or L1) retrotransposons are abundant and currently active retroelements in the human and mouse genomes. Similarly, long terminal repeat (LTR)-containing retrotransposons are abundant in both genomes, although only active in mice. LTR- and LINE-1-retroelements use different mechanisms for retrotransposition, although both involve the reverse transcription of an intermediate retroelement-derived RNA. Retrotransposon activity continues to effect the germline and somatic genomes, generating interindividual variability over evolution and potentially influencing cancer and brain physiology, respectively. However, relatively little is known about the functional consequences of retrotransposition. In this study, we have synthesized and characterized reverse transcriptase inhibitors specific for mammalian LINE-1 retrotransposons, which might help deciphering the functional impact of retrotransposition in vivo.
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