Journal
DNA REPAIR
Volume 30, Issue -, Pages 90-103Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2015.02.005
Keywords
XRCC1; DNA repair; DNA polymerase beta; DNA ligase 3 alpha; Single-strand break repair
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Funding
- Intramural Research Program of the NIH, National Institute of Environmental Health Sciences [1ZIA ES050111-26]
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Scaffold proteins play a central role in DNA repair by recruiting and organizing sets of enzymes required to perform multi-step repair processes. X-ray cross complementing group 1 protein (XRCC1) forms enzyme complexes optimized for single-strand break repair, but participates in other repair pathways as well. Available structural data for XRCC1 interactions is summarized and evaluated in terms of its proposed roles in DNA repair. Mutational approaches related to the abrogation of specific XRCC1 interactions are also discussed. Although substantial progress has been made in elucidating the structural basis for XRCC1 function, the molecular mechanisms of XRCC1 recruitment related to several proposed roles of the XRCC1 DNA repair complex remain undetermined. Published by Elsevier B.V.
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