Journal
DNA REPAIR
Volume 32, Issue -, Pages 127-133Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2015.04.023
Keywords
SWI/SNF; PBAF; BRG1; BAF180; Chromatin remodelling complex; Tumourigenesis; Genome instability; DNA damage induced transcriptional repression; Cohesion
Categories
Funding
- Cancer Research UK [C7905/A16417]
- Medical Research Council [MR/K001604/1]
- Cancer Research UK [16417] Funding Source: researchfish
- Medical Research Council [MR/K001604/1] Funding Source: researchfish
- MRC [MR/K001604/1] Funding Source: UKRI
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Genes encoding subunits of the two SWI/SNF chromatin remodelling complexes (BAF and PBAF) are mutated in almost 20% of all human cancers. In addition to a role in regulating transcription, recent work from our laboratory and others identified roles for both complexes in DNA damage responses and the maintenance of sister chromatid cohesion, which may have profound impacts on genome stability and contribute to its role as a tumour suppressor. Here, we review some of the transcription-independent functions of the SWI/SNF chromatin remodelling complex and discuss these in light of their potential relevance to tumourigenesis. (C) 2015 Elsevier B.V. All rights reserved.
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