Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 17, Issue 33, Pages 7632-7650Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob00772e
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Funding
- Jiangsu Government Scholarship for Overseas Studies [JS-2012-063]
- Jiangsu Oversea Visiting Scholar Program for University Prominent Youth & Middle-aged Teachers and Presidents
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Multicomponent reactions (MCRs) involving a minimum of three reactants or reaction centers are conducted in one pot and with a single operational step. This synthetic method has a good pot, atom and step economy in the preparation of diverse and complex molecular scaffolds. Consecutive MCRs, also known as sequential or multiple MCRs, by combining two or more MCRs, exhibit even higher synthetic efficiency, product structural diversity, and molecular complexity. This review article highlights the Ugi, Groebke-Blackburn-Bienayme, Biginelli, Huisgen, Petasis, Gewald, and Asinger reaction-initiated consecutive MCRs.
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