Journal
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
Volume 18, Issue 8, Pages 1910-1922Publisher
SPRINGERNATURE
DOI: 10.1039/c9pp00102f
Keywords
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Funding
- University of Aveiro [FCT UID/QUI/00062/2019, UID/AMB/50017/2019]
- FCT/MEC [FCT UID/QUI/00062/2019, UID/AMB/50017/2019]
- FEDER
- FEDER, within Compete 2020
- Portuguese NMR Network
- Universidade Federal Fluminence
- FAPERJ
- CNPQ
- CAPES [001]
- UFF
- FCT [BI/UI51/7965/2017]
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New porphyrin/4-oxoquinoline conjugates were synthesized from the Heck coupling reaction of a beta-brominated porphyrin with 1-allyl-4-oxoquinoline derivatives, followed by demetallation and deprotection affording the promising photosensitizers 9a-e. Singlet oxygen studies have demonstrated that all the porphyrin/4-oxoquinoline conjugates 9a-e were capable of producing cytotoxic species and found to be excellent photosensitizing agents in the inactivation of S. aureus by the antimicrobial photodynamic therapy (aPDT) protocol.
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