Journal
CHINESE JOURNAL OF ORGANIC CHEMISTRY
Volume 39, Issue 7, Pages 1867-1874Publisher
SCIENCE PRESS
DOI: 10.6023/cjoc201901029
Keywords
phenylalanine; C-H functionalization; alkylation; alkenylation; arylation
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Funding
- National Natural Science Foundation of China [21662017]
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Phenylalanine derivatives are widely found in a broad range of pharmaceutical molecules and exhibit significant biological activity. Direct C-H bond functionalization of phenylalanine derivatives to offer an efficient approach to construct C-I, C(sp(2))-C(sp(2)), C(sp(2))-C(sp), C(sp(2))-C(sp(3)), C-N, C-B and C-O bonds is described. The transformation involves ortho-C-H bond iodination and the following intramolecular amination, ortho-alkylation, ortho-arylation, ortho-alkenylation, ortho-alkynylation, ortho-acylation, ortho-acetoxylation, ortho-amination, ortho-boronation, meta-arylation and meta-alkylation.
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