Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 17, Issue 22, Pages 5509-5513Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob00857h
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Funding
- National Natural Science Foundation of China [21871174, 21672136, 21672140]
- Innovation Program of Shanghai Municipal Education Commission [2019-01-07-00-09-E00008]
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A copper nitrate-mediated [2 + 2 + 1] cycloaddition reaction was developed for the expedient synthesis of pharmacologically interesting 3-aryl substituted isoxazolines and isoxazoles through C = C bond cleavage. Copper nitrate is employed as a reaction promoter and precursor of nitrile oxides. The given approach features a new mode of cycloaddition from olefinic azlactones, copper nitrate and unsaturated compounds with wide substrate scope, good functional group tolerance and operational simplicity.
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