Journal
REGENERATIVE BIOMATERIALS
Volume 6, Issue 2, Pages 107-111Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rb/rby029
Keywords
dental implant; bone-grafting material; mineralized collagen
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Funding
- Beijing Municipal Science & Technology Commission Projects [Z181100002018001]
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The mechanism of the mineralization process induced by natural mineralized collagen (MC) has been investigated for decades. The purpose of this study was to investigate the efficacy of self-assembled MC for peri-implant bone defect reconstruction in a mini pig. A standardized peri-implant bone defect model was created using 14 mini pig mandibles. Two materials were evaluated, i.e. a mixture of hydroxyapatite and collagen (Type A, TA), and self-assembled MC (Type B, TB). Bio-Oss (BO) and untreated (blank control, BC) groups were used as controls. After 3- and 6-month healing periods, the mini pigs were sacrificed for histomorphometric and microcomputed tomography analysis. After 3 months of healing, the average alveolar ridge height was 3.27 +/- 1.57 mm for group TA, 3.28 +/- 2.02 mm for group TB and 3.37 +/- 1.09 mm for group BO, while group BC showed the lowest height of 2.68 +/- 0.47 mm. After 6 months of healing, the average alveolar ridge height was 2.64 +/- 1.13 mm for group TA, 4.31 +/- 1.80 mm for group TB and 3.87 +/- 1.38 mm for group BO, while group BC showed the lowest height of 2.48 +/- 1.80 mm. The experimental groups and control group showed similar bone volume density, bone complexity and histological reaction. The self-assembled MC (Type B) stimulated new bone formation in the reconstruction of deficient alveolar ridges around the dental implant; it also displayed excellent clinical operability compared with bone grafts without collagen.
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