Journal
BIOMATERIALS SCIENCE
Volume 7, Issue 9, Pages 3918-3925Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9bm00960d
Keywords
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Categories
Funding
- National Natural Science Foundation of China [51703105, 21574072, 21675091, 21874078]
- Natural Science Foundation of Shandong Province [ZR2017BEM012]
- Taishan Young Scholar Program of Shandong Province [tsqn20161027]
- Major Science and Technology Innovation Project of Shandong Province [2018CXGC1407]
- Key Research and Development Project of Shandong Province [2016GGX102028, 2016GGX102039, 2017GGX20111]
- China Postdoctoral Science Foundation [2018M630752]
- People's Livelihood Science and Technology Project of Qingdao [166257nsh, 173378nsh]
- Innovation Leader Project of Qingdao [168325zhc]
- Postdoctoral Scientific Research Foundation of Qingdao
- First Class Discipline Project of Shandong Province
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Polymer gels can be classified as chemical and physical gels, depending on the type of cross-link. Physical gels usually form by physical cross-linking, such as hydrogen bonding, van der Waals and/or p-p interactions, which can avoid the use of additional cross-linking agents. Polyamidoamine (PAMAM) dendrimers possess abundant active groups on their surfaces. Modified dendrimers have been used as versatile linkers in some projects. In this work, polymer gels composed of PAMAM dendrimers without any covalent bonding cross-linking agents were prepared. The number of amino groups and ester groups on the surface of the dendrimers was precisely regulated to help form hydrogen bonds between adjacent dendrimers. The prepared dendrimer-based polymer gels retain the properties of PAMAM dendrimers such as antibacterial properties, and the unique structures make the gels exhibit high compressive strengths but relatively low tensile strengths. Interestingly, the prepared gels show good anti-inflammatory properties in acute inflammation models of mice with ear edema. The inflammatory inhibition rate and hematoxylin-eosin (H&E) staining method were used to confirm the anti-inflammatory effect. This present study demonstrates that the dendrimer-based polymer gels achieved through hydrogen bonding could be a versatile platform for tissue engineering.
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