4.6 Article

A naphthalimide-indole fused chromophore-based fluorescent probe for the detection of biothiol with red emission and a large Stokes shift

Journal

NEW JOURNAL OF CHEMISTRY
Volume 43, Issue 33, Pages 13212-13216

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9nj02709b

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Funding

  1. Industry-Academia-Research project of Zhengzhou University [130-52110779]
  2. Foundation for young teachers' SpecialResearch-Initiation in Zhengzhou University
  3. Synergy-Innovation-Major-Project in Zhengzhou [18XTCX12001]

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In this work, a fluorescent probe, 1, using naphthalimide-indole as a fluorophore and a 2,4-dinitrobenzene sulfonyl group as a recognition site for biothiols (GSH, Cys and Hcy) was developed. The probe can work in aqueous media with a rapid response time (within 4 min). In the detection of biothiols, the probe showed red emission (590 nm), low detection limits (8.97 x 10(-9) M for GSH, 9.87 x 10(-9) M for Cys, and 1.02 x 10(-8) M for Hcy) and a 143 nm Stokes shift. Moreover, this probe exhibited potential practical applications for detecting biothiols in living cells.

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