Journal
ACS APPLIED BIO MATERIALS
Volume 2, Issue 9, Pages 3722-3729Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.9b00220
Keywords
photothermal therapy; chemotherapy; upconversion luminescence; injectable hydrogels; gelatin
Funding
- National Natural Science Foundation of China [20474005]
- NSFC Program of China [51574267]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_14R58]
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Diagnosis and multitherapy strategies that coexist in a single system for cancer therapy has a great clinical application potential. In this paper, we developed doxorubicin (DOX)-loaded gelatin hydrogels contained with UCNP@NGO nanoparticles (Gelatin/UCNP@NGO+DOX) for chemophotothermal dual-model synergistic cancer therapy and upconversion luminescence (UCL) imaging. Gelatin/UCNP@NGO+DOX hydrogels could release the DOX via laser irradiation or in tumor microenvironment, and then cancer therapy efficiency could be improved by chemophotothermal synergistic effects. In vitro experimental Gelatin/UCNP@NGO+DOX hydrogels exhibit outstanding photothermal properties and excellent tumor-killing efficiency. We also use in vivo antitumor experiments to further illustrate that Gelatin/UCNP@NGO+DOX hydrogels can exhibit excellent synergistic antitumor efficacy, compared with chemotherapy or photothermal methods. This paper shows a new hydrogel system that could both load chemotherapeutic drugs efficiently and enhance chemotherapy effect using near-infrared light-radiation photothermal therapy.
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