Journal
ANALYST
Volume 144, Issue 16, Pages 4733-4749Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9an00558g
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Funding
- EPSRC [EP/P001440/1, EP/R031118/1, 1946866] Funding Source: UKRI
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The constantly growing field of True One Cell (TOC) analysis has provided important information on the direct chemical composition of various cells and cellular components. Since the heterogeneity of individual cells has been established, more researchers are interested in the chemical differences between individual cells; TOC is the only form of analysis that can provide this information. This has resulted in the constant development of new technologies and methods. This review highlights the common techniques for micro- and nanomanipulation, Raman spectroscopy, microscopy, and mass spectrometric imaging as they pertain to TOC chemical analysis.
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