Journal
IMMUNE NETWORK
Volume 19, Issue 4, Pages -Publisher
KOREA ASSOC IMMUNOLOGISTS
DOI: 10.4110/in.2019.19.e25
Keywords
B7-1 antigen; Extrinsic acquisition; Trogocytosis; Recall immune response; Lymphocytic choriomeningitis virus
Categories
Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2015R1A2A1A10056084, 2017R1A5A1014560, 2018R1A2A1A05076997, 2018M3A9H3024850, 2019M3A9B6065221]
- National Research Foundation of Korea [2018M3A9H3024850, 2019M3A9B6065221, 2018R1A2A1A05076997, 2015R1A2A1A10056084, 2017R1A5A1014560] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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CD80 is mainly expressed on Ag-presenting cells (APCs) as a costimulatory molecule but is also detected on T cells. However, the origin and physiological role of CD80 on CD8(+)T cells remain unclear. In the present study, we demonstrated that effector and memory CD8(+)T cells, but not naive CD8(+)T cells, displayed CD80 molecules on their surfaces after acute lymphocytic choriomeningitis virus infection. Using adoptive transfer of CD80-knockout (KO) CD8(+)T cells into a wild type or CD80-KO recipient, we demonstrated that the effector CD8(+)T cells displayed CD80 by both intrinsic expression and extrinsic acquisition, while memory CD8(+)T cells displayed CD80 only by extrinsic acquisition. Interestingly, the extrinsic acquisition of CD80 by CD8(+)T cells was observed only in the lymphoid organs but not in the periphery, indicating the trogocytosis of CD80 molecules via interaction between CD8(+)T cells and APCs. We compared the recall immune responses by memory CD8(+)T cells that either extrinsically acquired CD80 or were deficient in CD80, and found that CD80, presented by memory CD8(+)T cells, played a role in limiting their expansion and IL-2 production upon exposure to secondary challenge. Our study presents the in vivo dynamics of the extrinsic acquisition of CD80 by Ag-specific CD8(+)T cells and its role in the regulation of recall immune responses in memory CD8(+)T cells.
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