Journal
MEDICAL IMAGING 2019: PHYSICS OF MEDICAL IMAGING
Volume 10948, Issue -, Pages -Publisher
SPIE-INT SOC OPTICAL ENGINEERING
DOI: 10.1117/12.2512467
Keywords
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Funding
- National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health [R01EB020521]
- Office of the Assistant Secretary of Defense for Health Affairs, through the Breast Cancer Research Program [W81XWH-16-1-0031]
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In 1963, Shaw applied Fourier analysis to the zero-frequency DQE and developed the frequency-dependent DQE or DQE(k) and made it clear that DQE(k) is applicable to every frequency level within the system bandwidth, including the zero frequency. Over time, especially after entering the modern era of digital x-ray imaging, the experimental measurement methods of DQE(k) (particularly the measurements of the NPS which is an important element in DQE(k)) have evolved, and some measurement methods may generate nonphysical NPS and DQE results at k=0. As a result, an experimental DQE(k) curve is often cut off at certain low frequency above zero. This work presents a new experimental method to deal with two challenges: severe NPS(k=0) underestimation due to polynomial-based background detrending; severe NPS(k=0) overestimation due to the presence of faint but non-negligible system drift. Based on a theoretical analysis of the impact of drift to the measured autocovariance function, the error introduced by drift can be isolated, and corresponding correction can be applied to NPS(k=0). Both numerical simulation with known ground truth and experimental studies demonstrated that the proposed method enables accurate DQE(k=0) measurement.
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